Volume 14, Number 1, March 2002

Effect of Highly Active Antiretroviral Therapy on Oral Manifestations of Human Immunodeficiency Virus Infection in Japanese Patients

Yoshinari Morimoto, Masako Ikeuchi, Kazuhiko Yamamoto, Tadaaki Kirita, Masahito Sugimura
Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan

Objective: Protease inhibitors became available in Japan in April 1997. This study was performed to compare changes in oral manifestations between the pre- and post-highly active antiretroviral therapy periods in Japanese patients with human immunodeficiency virus infection.
Patients and Methods: Twenty seven Japanese patients with human immunodeficiency virus infection were investigated. The backgrounds (age, sex, and risk group), immune status at first visit and changes with time, associated systemic diseases, and oral manifestations were examined using patients' clinical records.
Results: Although pseudomembranous candidiasis decreased significantly (p < 0.05), other oral manifestations did not change. These results were obtained for patients with CD4+ lymphocytes of 499 to 200/mm3, with no change recorded for patients with CD4+ lymphocytes of <200/mm3.
Conclusion: Oral candidiasis was considered easy to control with improvement of the immune status.

Key words: Oral manifestations, Human immunodeficiency virus infection, Antiretroviral therapy, highly active

Asian J Oral Maxillofac Surg. 2002;14:21-26.
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