Volume 14, Number 1, March 2002

CyberKnife After Failed Conventional Therapy for Oral Squamous Cell Carcinoma: Report of 2 Patients

Takanori Ishimaru,1 Yuzo Mizugaki,1 Yoshikazu Hayatsu,1 Kenichi Saito,2 Fumihiko Shinozaki1
1Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
1Department of Neurosurgery, Konan St Hill Hospital, Ube, Yamaguchi, Japan

CyberKnife® is a stereotactic radiosurgery system used to treat solid tumours. Two patients with inoperable oral squamous cell carcinoma treated with CyberKnife are presented in this report. A 64-year-old woman with extensive invasion of the primary tumour received superselective intra-arterial chemoradiotherapy, followed by CyberKnife, and obtained a complete response. A 75-year-old man with recurrent tumour in the base of the skull after surgery underwent CyberKnife, but did not achieve a good response. The total dose of irradiation for each patient was more than 100 Gy by way of even fractionated irradiation of 2 Gy/fraction, and there was no evidence of severe damage to the adjacent normal tissues. Although CyberKnife is not a candidate for first choice treatment for oral squamous cell carcinoma, it may be a good option for rescue after failed conventional therapies.

Key words: Mouth neoplasms, Fractionation, Radiation

Asian J Oral Maxillofac Surg. 2002;14:40-43.
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