Volume 14, Number 2, June 2002

Prevalence of Hepatitis B, C, and G Virus Infection in Patients With Oral Cancer or Jaw Cysts

Yutaka Takata,1 Jinichi Fukuda,2 Hideo Kurokawa3
1Department of Internal Medicine, Kyushu Dental College, Kitakyushu, Japan
2First Department of Oral Surgery, Kyushu Dental College, Kitakyushu, Japan
3Second Department of Oral Surgery, Kyushu Dental College, Kitakyushu, Japan


Abstract
Objectives: The prevalences of hepatitis B, C, and G virus infections were compared between dental patients admitted to hospital with oral cancers and oral cysts.
Patients and Methods: In patients with cancer (n = 195) or cysts (n = 256), sera were tested for hepatitis G virus RNA by reverse transcription-polymerase chain reaction, and also for hepatitis B surface antigen and hepatitis C virus antibody.
Results: Thirteen of 441 patients (2.9%) were infected with hepatitis G virus, 5 of 420 (1.2%) with hepatitis B virus, and 24 of 400 (6.0%) with hepatitis C virus. Age was similar for patients with and without hepatitis G or hepatitis B virus infection, but patients with hepatitis C virus infection were older than those without the virus (p = 0.009). Among patients with oral cancer, 6 of 190 (3.2%) were infected with hepatitis G virus, a prevalence similar to that of patients with oral cysts (2.8%). No patients with cancer were infected with hepatitis B virus, but 5 of 235 patients (2.1%) with cysts had hepatitis B virus infection, representing a significant difference (p = 0.046). Hepatitis C virus antibody tended to be more prevalent in patients with cancer (8.6%) than in those with cysts (4.0%; p = 0.053).
Conclusion: The prevalence of hepatitis G virus infection was similar in patients with oral cancer and jaw cysts. However, the prevalence of hepatitis B virus infection was lower in patients with cancer than in those with oral cysts, while the reverse was true for hepatitis C virus infection. Overall, hepatitis C virus infection was the most prevalent and hepatitis B virus infection was the least prevalent.


Key words: Cysts, GB virus C, Hepacivirus, Hepatitis B virus, Neoplasms, Oral medicine, Surgery, oral

Asian J Oral Maxillofac Surg. 2002;14:82-86.
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