Volume 14, Number 4, December 2002
| | Histological Investigation of Veins and Venous Malformations after Injection of Sclerosing Agents |
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Ji-Hong Zhao,1 Yi-Fang Zhao,1 Xing-Ming Chen,2 Xiang Zheng,1 Wen-Fen Zhang1
1Department of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Wuhan University, Wuhan, China
2Department of Oral Pathology, College and Hospital of Stomatology, Wuhan University, Wuhan, China
Abstract
Objective: To study the histological changes of veins and venous malformations after injection of pingyangmycin and sodium morrhuate.
Patients and Methods: Pingyangmycin and sodium morrhuate were injected into the marginal auricular veins of the left and right ears of rabbits and histological changes in vessels were observed. Surgical excision of clinical venous malformations in the oral and facial regions was performed for 25 patients after sclerotherapy. The histological changes in the resected lesions were observed.
Results:After pingyangmycin injection, obvious changes of veins and venous malformations occurred. Endothelial cells were swollen and vacuolised, tunica intima was discontinuous, thickness of the vessel wall was increased, and lumen was narrowed and occluded. Following injection of sodium morrhuate, intraluminal thrombus was formed and organised, the lumen was obstructed, and a strong inflammatory reaction was observed in nearby tissues.
Conclusion: Injection of pingyangmycin and sodium morrhuate into veins and venous malformations can cause injury to endothelial cells, thickening of the vessel wall, and narrowing or occlusion of vessels. Pingyangmycin leads to less inflammatory reaction in extravascular tissues than sodium morrhuate.
Key words: Veins, Venous malformations, Sodium morrhuate
Asian J Oral Maxillofac Surg. 2002;14:226-231.
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