Volume 15, Number 2, June 2003

Comparison of CYFRA 21-1 with Squamous Cell Carcinoma Antigen and Relationship with Anti-cytokeratin 19 Antibody Staining in Oral Squamous Cell Carcinoma

Seiji Obara, Yoshiki Nariai, Yasuro Yoshimura

Department of Oral and Maxillofacial Surgery, School of Medicine, Shimane Medical University, Izumo, Japan

Abstract
Objective: To distinguish a reliable marker for oral squamous cell carcinoma.
Patients and Methods: Serum levels of CYFRA 21-1 and squamous cell carcinoma-antigen were compared, and the relationship of CYFRA 21-1 with immunohistochemical staining of anti-cytokeratin 19 antibody was evaluated in 40 patients with oral squamous cell carcinoma. Twenty six biopsy specimens obtained from previously untreated patients were immunohistochemically stained using the streptoavidin-biotin-peroxidase complex method with cytokeratin 19 monoclonal antibody. Tissue levels of CYFRA 21-1 were also measured in 3 patients with squamous cell carcinoma.
Results: CYFRA 21-1 revealed almost the same sensitivity as squamous cell carcinoma-antigen in patients with oral squamous cell carcinoma (40.0% and 35.0%, respectively), and there was no correlation between these 2 makers (r = 0.007). There was no relationship between the immunoreactivity with cytokeratin 19 antibody and the serum levels of CYFRA 21-1. High CYFRA 21-1 levels in squamous cell carcinoma tissue were observed.
Conclusion: A combination assay of CYFRA 21-1 and squamous cell carcinoma-antigen is a useful technique for monitoring and screening of oral squamous cell carcinoma. Tissue levels of CYFRA 21-1 and the immunoreactivity of cytokeratin 19 suggest that serum CYFRA 21-1 were affected by not only the expression of cytokeratin 19 in squamous cell carcinoma cells but also by the release of cytokeratin 19 soluble fragment (CYFRA 21-1) from squamous cell carcinoma cells.

Key words:
Antigen, Squamous cell carcinoma, Tumor markers

Asian J Oral Maxillofac Surg. 2003;15:107-111.
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