Volume 15, Number 2, June 2003

Comparison of CYFRA 21-1 with Squamous Cell Carcinoma Antigen and Relationship with Anti-cytokeratin 19 Antibody Staining in Oral Squamous Cell Carcinoma

Seiji Obara, Yoshiki Nariai, Yasuro Yoshimura

Department of Oral and Maxillofacial Surgery, School of Medicine, Shimane Medical University, Izumo, Japan

Objective: To distinguish a reliable marker for oral squamous cell carcinoma.
Patients and Methods: Serum levels of CYFRA 21-1 and squamous cell carcinoma-antigen were compared, and the relationship of CYFRA 21-1 with immunohistochemical staining of anti-cytokeratin 19 antibody was evaluated in 40 patients with oral squamous cell carcinoma. Twenty six biopsy specimens obtained from previously untreated patients were immunohistochemically stained using the streptoavidin-biotin-peroxidase complex method with cytokeratin 19 monoclonal antibody. Tissue levels of CYFRA 21-1 were also measured in 3 patients with squamous cell carcinoma.
Results: CYFRA 21-1 revealed almost the same sensitivity as squamous cell carcinoma-antigen in patients with oral squamous cell carcinoma (40.0% and 35.0%, respectively), and there was no correlation between these 2 makers (r = 0.007). There was no relationship between the immunoreactivity with cytokeratin 19 antibody and the serum levels of CYFRA 21-1. High CYFRA 21-1 levels in squamous cell carcinoma tissue were observed.
Conclusion: A combination assay of CYFRA 21-1 and squamous cell carcinoma-antigen is a useful technique for monitoring and screening of oral squamous cell carcinoma. Tissue levels of CYFRA 21-1 and the immunoreactivity of cytokeratin 19 suggest that serum CYFRA 21-1 were affected by not only the expression of cytokeratin 19 in squamous cell carcinoma cells but also by the release of cytokeratin 19 soluble fragment (CYFRA 21-1) from squamous cell carcinoma cells.

Key words:
Antigen, Squamous cell carcinoma, Tumor markers

Asian J Oral Maxillofac Surg. 2003;15:107-111.
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