Volume 15, Number 2, June 2003

Biochemical Aspects of the Pathogenesis of Temporomandibular Joint Disorders

Mihoko Tomida,1 Jun-Ichi Ishimaru,2 Ken Miyamoto,3 Takumi Mizui,2 Yuki Esaki,3 Tomoya Hayashi,1 Koichi Murayama,1 Seiich Era,1 Toshiyuki Shibata3

1Department of Biochemistry and Biophysics, Gifu University School of Medicine, Gifu, Japan
2Department of Oral and Maxillofacial Surgery, Gifu Prefectural Gifu Hospital, Gifu, Japan
3Department of Oral and Maxillofacial Science, Gifu University School of Medicine, Gifu, Japan

Various molecular and inflammatory mediators, and matrix metabolites have been reported in the synovial fluid of patients with temporomandibular joint disorders. Additionally oxidative stress and the accumulation of free radicals may lead to tissue damage in all tissues, including the temporomandibular joint. These molecular events can trigger the degradation of collagen, hyaluronic acid, and proteoglycans, leading to the development of articular pathology. In this paper, the literature is reveiwed with an emphasis on synovial fluid, and the scientific evidence categorised to theoretically consider the aetiology and pathology of temporomandiblar joint disorders.

Key words: Albumins, Antioxidants, Free radicals, Temporomandibular joint disorder

Asian J Oral Maxillofac Surg. 2003;15:118-127.
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