Volume 15, Number 2, June 2003

Cystic Basal Cell Adenoma of the Parotid Gland with an Adenoid Cystic Carcinoma-like Structure

Masakatsu Fukuda,1 Masaru Miyata,2 Koichi Okabe,2 Hiroshi Kurumaya,3 Kouichi Nagao,4 Hideaki Sakashita,1 Kaoru Kusama5

1Second Department of Oral and Maxillofacial Surgery, Meikai University School of Dentistry, Saitama, Japan
2Department of Dentistry and Oral Surgery, Ishikawa Prefectural Central Hospital, Ishikawa, Japan
3Department of Pathology, Ishikawa Prefectural Central Hospital, Ishikawa, Japan
4Department of Surgical Pathology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan
5Department of Oral Pathology, Meikai University School of Dentistry, Saitama, Japan

Abstract
Basal cell adenoma is a rare disease that was introduced as an entity by the World Health Organization in 1991. Histologically, this tumour can be easily confused with basal cell adenocarcinoma and the solid basaloid subtype of adenoid cystic carcinoma. In this report, immunohistochemical methods were used for accurate diagnosis. No reaction for cytokeratin 10/13 was observed. The distribution of cytokeratin 14 was localised in the outer layer of the tubular patterns and the duct-like structures of the adenoid cystic carcinoma-like nest. The reactions for cytokeratin 18 and cytokeratin 19 were positive in the inner layer of tubular patterns. The immunoreactivity for S-100 protein closely corresponded with that for cytokeratin 18. The reaction for Ki67 was slight positive. These findings indicate that histopathological and immunohistochemical analysis might be useful discrimination techniques for the diagnosis, treatment, and prognosis of parotid gland tumours.

Key words:
Basal cell adenoma, Cytokeratin, Immunohistochemistry, Parotid gland

Asian J Oral Maxillofac Surg. 2003;15:128-134.
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