Volume 15, Number 4, December 2003

Expression of rasp21, c-erbB-2, and p53 and Implications on Biological Behaviour of Parotid Pleomorphic Adenoma

Achmad Syawqie

Anatomical Pathology Department, School of Dentistry and Medicine, Padjadjaran University (UNPAD), and Hasan Sadikin Central General Hospital, West Java, Indonesia

Abstract
Objective: To examine the expression of rasp21, c-erbB-2, and p53 in parotid pleomorphic adenoma in an attempt to improve the predictability of the tumour's biological behaviour in relation to borderline malignancy.
Patients and Methods: Twenty five benign and 17 malignant parotid pleomorphic adenoma specimens were collected from the files of 4 institutions during a 16-year period (1980 to 1986). Re-examination of specimens was done using immunohistochemical techniques. Immuno-expression was graded according to the following criteria: 0 = negative; +1 = focal (<20%); +2 = heterogenous (20-50%), and +3 = diffuse (>50%). Heterogenous and diffuse were considered to be overexpression.
Results:Significant expression of rasp21 (88.1%), c-erbB-2 (92.8%), and p53 (97.6%) was noted. Sensitivity and negative predictive value were 100%. However, specificity was 50% and false positivity was encountered in benign tumours only.
Conclusion: rasp21, c-erbB-2, and p53 expression in parotid pleomorphic adenoma may point to a role in predicting borderline malignancy.

Key words:
Adenoma, Genes, erbB-2, Genes, p53, Genes, ras, Oncogene, Parotid cancer

Asian J Oral Maxillofac Surg. 2003;15:261-267.

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