Volume 15, Number 4, December 2003
| | Expression of rasp21, c-erbB-2, and p53 and Implications on Biological Behaviour of Parotid Pleomorphic Adenoma |
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Achmad Syawqie
Anatomical Pathology Department, School of Dentistry and Medicine, Padjadjaran University (UNPAD), and Hasan Sadikin Central General Hospital, West Java, Indonesia
Abstract
Objective: To examine the expression of rasp21, c-erbB-2, and p53 in parotid pleomorphic adenoma in an attempt to improve the predictability of the tumour's biological behaviour in relation to borderline malignancy.
Patients and Methods: Twenty five benign and 17 malignant parotid pleomorphic adenoma specimens were collected from the files of 4 institutions during a 16-year period (1980 to 1986). Re-examination of specimens was done using immunohistochemical techniques. Immuno-expression was graded according to the following criteria: 0 = negative; +1 = focal (<20%); +2 = heterogenous (20-50%), and +3 = diffuse (>50%). Heterogenous and diffuse were considered to be overexpression.
Results:Significant expression of rasp21 (88.1%), c-erbB-2 (92.8%), and p53 (97.6%) was noted. Sensitivity and negative predictive value were 100%. However, specificity was 50% and false positivity was encountered in benign tumours only.
Conclusion: rasp21, c-erbB-2, and p53 expression in parotid pleomorphic adenoma may point to a role in predicting borderline malignancy.
Key words: Adenoma, Genes, erbB-2, Genes, p53, Genes, ras, Oncogene, Parotid cancer
Asian J Oral Maxillofac Surg. 2003;15:261-267.
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