Volume 15, Number 4, December 2003

Radicular Cysts in the Mandible with Ciliated Columnar Epithelial Lining - Report of 3 Patients Including Keratin Expression Findings

Tsuyoshi Kimura, Toyohiro Tanida, Tetsuya Yamamoto, Yukihiro Tatemoto, Akihiko Ohno, Tokio Osaki

Department of Oral Surgery, Kochi Medical School, Kochi, Japan

Objective: To examine 3 radicular cysts, which appeared to be atypical glandular odontogenic cysts.
Patients and Methods: Histological and immunohistochemical investigation of 3 extirpated radicular cysts of 3 patients, using cytokeratin 13 and 18 expression was performed and the findings compared with those of normal oral epithelium, radicular cyst, and postoperative maxillary cyst.
Results: The cysts were lined with ciliated columnar epithelium with a few mucicarmine positive cells. None of the cyst linings contained papillary projections, crypt-like depression, and luminal epithelial plaques, which are characteristic of glandular odontogenic cysts. Immunohistochemically, the 3 cyst linings were positive for cytokeratin 18 and cytokeratin 13, although the cytokeratin 13 expression intensity varied from strong to weak. Cytokeratin 18 was expressed on the upper layers, while cytokeratin 13 was expressed in the middle layers.
Conclusion: From these clinical and histological appearances, the 3 cysts were regarded as glandular odontogenic cysts although they are not typical for glandular odontogenic cysts.

Key words:
Ciliated columnar epithelium, Cytokeratin, Odontogenic cyst, Radicular cyst

Asian J Oral Maxillofac Surg. 2003;15:268-273.

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