Volume 16, Number 1, March 2004

Correlation of p27kip1 and Cyclin D1 Proteins with Growth Activity in Grade 1 Oral Squamous Cell Carcinoma in Myanmar: a Preliminary Study

Shwe Toe,1 Aye Aye Thike,2 Ba Myint,3 Aye Aye Myint,2 Minoru Takagi4

1Department of Oral Medicine, Institute of Dental Medicine, Mandalay, 2Department of Pathology, Institute of Medicine (2), Yangon, 3Department of Oral Medicine, Institute of Dental Medicine, Yangon, Myanmar, and 4Department of Molecular Pathology, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Japan


Abstract
Objective:
To identify the cell cycle-related proteins in World Health Organization grade 1 oral squamous cell carcinoma and to correlate the immunoreactivity of these proteins with clinicopathological parameters.
Patients and Methods: 24 patients with oral squamous cell carcinoma, were enrolled. P27kip1 and cyclin D1 expression in the tumours were determined by immunohistochemical staining of paraffin sections. Brown staining of tumour cell nuclei was regarded as positive immunoreactivity.
Results: p27kip1 and cyclin D1 immunoreactivity was observed in 13 (54%) and 9 (37%) patients, respectively. Although p27kip1 expression in oral squamous cell carcinoma did not statistically correlate with clinicopathological parameters, cyclin D1 expression was significantly associated with mitotic count (p = 0.002). P27kip1 immunoreactivity was found to be inversely associated with cyclin D1 expression (p = 0.002; r = 0.54).
Conclusion: Cyclin D1 immunoreactivity may be useful as a proliferation marker for World Health Organization grade 1 oral squamous cell carcinoma.


Key words: Cyclin D1, Oral, Squamous cell carcinoma

Asian J Oral Maxillofac Surg. 2004;16:34-37.
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