Volume 16, Number 1, March 2004

Salivary Duct Carcinoma of the Minor Salivary Glands

Akiyuki Maeda, Tsunehisa Shimoda, Satoru Ozeki, Takeshi Honda

Department of Oral and Maxillofacial Surgery, Fukuoka Dental College, Fukuoka, Japan

Salivary duct carcinoma is characterised by aggressive behaviour, with a high risk of local recurrence, and regional and distant metastasis. This report describes a patient with salivary duct carcinoma that originated in the minor salivary glands of the mucosa over the maxilla. Microscopically, vascular invasion varied from 4 to 5 per 10 high-power fields, and immunohistochemical staining with E26 transformation specific-1 was demonstrated in the tumour cells. Ki67 positivity was also revealed in 52% of the specimens examined. These results suggest that salivary duct carcinoma is a highly aggressive malignant salivary gland tumour due to proliferative cell activity, angiogenesis, and vascular invasion.

Key words:
Ki67, Minor salivary gland, Salivary duct carcinoma, Vascular invasion

Asian J Oral Maxillofac Surg. 2004;16:51-55.
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