Volume 16, Number 2, June 2004

Mutation of p53 as a Prognostic Indicator in Patients with Oral Squamous Cell Carcinoma

Nobuyuki Tanaka,1 Tetsuyo Odajima,2 Kazuhiro Ogi,1 Masaaki Satoh2

1Department of Oral Surgery, Sapporo Medical University School of Medicine and 2Department of Clinical Pathology, Sapporo Medical University Hospital, Sapporo, Japan


Abstract
Objective: The p53 gene is frequently mutated in patients with oral squamous cell carcinoma. However, the correlation between the mutation of the p53 gene and the prognosis for patients with oral squamous cell carcinoma is uncertain and this was investigated in this study.
Patients and Methods: The correlation between the p53 mutation and the clinicopathological features of oral squamous cell carcinoma were examined. Samples were obtained from 81 patients with oral squamous cell carcinoma and the protein expression of p53 and the presence of mutation in exons 5 to 8 were investigated by immunohistochemistry and single-stranded conformation polymorphism, respectively.
Results: Overexpression of p53 was found in 40 patients, and there was a correlation between its expression and the degree of differentiation, meaning that many p53 overexpressed tumours were poorly differentiated. However, there was no correlation between p53 expression and the 5-year cumulative survival rate. Mutation of p53 was recognised in 29 patients and the 5-year cumulative survival rate of patients with p53-mutated tumours was significantly lower than that of patients without p53 mutation. However there was no correlation between the presence of mutation and other clinicopathological features.
Conclusion: From these results, it is suggested that p53 mutation may be a prognostic indicator for oral squamous cell carcinoma.

Key words:
Oral squamous cell carcinoma, p53 Mutation, Prognosis

Asian J Oral Maxillofac Surg. 2004;16:116-122.
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