Volume 16, Number 3, September 2004
| | HER2/neu Expression in Oral Squamous Cell Carcinoma |
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Satoru Shintani, Yuuji Nakahara, Chunnan Li, Mariko Mihara, Koh-ichi Nakashiro, Hiroyuki Hamakawa
Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, Ehime, Japan
Abstract
Objective: To evaluate the expression of HER2/neu in oral squamous cell carcinoma with a view to determining the usefulness of molecular target therapy by anti-HER2 antibody.
Patients and Methods: Oral squamous cell carcinoma cell lines and 69 clinical tumour samples were tested using enzyme-linked immunosorbent assay and immunohistochemistry. Positive and negative controls were utilised.
Results: Expression of HER2/neu in oral squamous cell carcinoma cell lines was low. Overexpression was not observed in the clinical samples.
Conclusion: Low prevalence of expression of HER2/neu in oral squamous cell carcinoma limits the likely utility of herceptin therapy
Key words: HER2/neu, Immunohistochemistry, Squamous cell carcinoma
Asian J Oral Maxillofac Surg. 2004;16:172-176.
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