Volume 18, Number 2, June 2006

Solitary Neurofibroma of the Mandible

Shinichiro Sumitomo,1 Kenji Ohno,1 Goh Mizutani,1 Takahisa Ohta,1 Kazuto Yamada,2 Yoshiaki Takai1
1Department of Oral and Maxillofacial Surgery, Division of Oral Pathogenesis and Disease Control, Asahi University School of Dentistry, Gifu, and 2Department of Dentistry and Oral Surgery, Fukui Red Cross Hospital, Fukui, Japan

Abstract
Central neurofibroma of the mandible is a rare tumour. This report is of a 21-year-old Japanese man with a symptomatic solitary neurofibroma of the left mandible. The tumour was excised with preservation of the mandibular nerve. The tumour consisted of proliferated dense collagen fibres and scattered spindle cells without mitotic figures or atypism. Immunohistochemistry showed that tumour cells were positive for vimentin, S100 protein, neurone specific enolase, and glial fibrillary acidic protein, but negative for desmin and a -smooth muscle actin. The diagnosis of neurofibroma was distinguished from a desmoplastic fibroma by the immunohistochemical findings.

Key words: Immunohistochemistry, Mandible, Neurofibroma

Asian J Oral Maxillofac Surg. 2006;18:142-5.
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