Volume 18, Number 2, June 2006

Kimura's Disease

Kittipong Dhanuthai,1 Pornchai Jansisyanont,2 Prasan Tangjaturonrasami,2 Kanjana Amornpitakpunt2
1Department of Oral Pathology, and 2Department of Oral and Maxillofacial Surgery, Chulalongkorn University , Bangkok , Thailand


Abstract
Kimura's disease is a benign chronic condition of unknown cause. It afflicts mainly Oriental populations, especially Chinese and Japanese people. Kimura's disease usually presents with a painless swelling of subcutaneous tissue in the head and neck region, especially in the major salivary glands and regional lymph nodes. Kimura's disease has been confused with angiolymphoid hyperplasia with eosinophilia. However, angiolymphoid hyperplasia with eosinophilia can be distinguished from Kimura's disease by differences in clinical and histopathological features. This report is of a 46-year-old Karen man with Kimura's disease. The patient developed progressive swelling in the left cheek and parotid gland as well as lymphadenopathy in the submandibular and submental regions. Histopathological examination revealed typical characteristics of Kimura's disease. He was treated by superficial parotidectomy and local excision for his left cheek lesion. Recurrence was observed 1 year after the surgery. The pathogenesis, treatment modalities, and differences between Kimura's disease and angiolymphoid hyperplasia with eosinophilia are discussed.

Key words: Angiolymphoid hyperplasia with eosinophilia, Kimura's disease

Asian J Oral Maxillofac Surg. 2006;18:151-6.

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