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Volume 19, Number 4, December 2007

Thrombocytopaenia Associated with Loxoprofen Sodium


Jun Sato, Jun Goto, Takumi Kato, Michiko Terada, Akira Satoh, Yoshimasa Kitagawa
Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan

Abstract 
Loxoprofen sodium is a phenyl propionic acid non-steroidal anti-inflammatory drug with a very good safety record. An unusual case of thrombocytopaenia most likely induced by loxoprofen sodium is reported. An 82-year-old woman developed thrombocytopaenia after taking loxoprofen sodium (180 mg/day) during treatment for trigeminal neuralgia and hip bone contusion. The patient’s platelet count fell to 24,000/mm3, but her condition improved after discontinuing loxoprofen sodium.

Key words: Anti-inflammatory agents, non-steroidal, Loxoprofen, Thrombocytopenia, Trigeminal neuralgia

Asian J Oral Maxillofac Surg. 2007;19:226-229.

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