Volume 20, Number 2, June 2008
| | Multiple Primary Oral Cancers |
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Hisao Shigematsu,1 Keiichi Hosokawa,1 Masaaki Kaburagi,1 Akio Tanaka,2 Kaoru Kusama,2 Hideaki Sakashita1
1Second Division of Oral and Maxillofacial Surgery and 2Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan
Abstract
This study reports 5 patients with multiple primary oral cancers. The tumours were synchronous in 3 patients and metachronous in 2. Histopathologically, 11 squamous cell carcinomas were recognised in these 5 patients, and 5 of these were early cancers with superficial invasion. Precancerous lesions or conditions were possibly associated with multiple primary oral cancers in 4 patients (1 male and 3 females). Although management with chemotherapy, radiotherapy, and/or surgery was employed, 2 of the 5 patients died of oral cancer. This study emphasises that careful examination of the entire oral cavity and rigid follow-up are essential for a successful outcome.
Key words: Carcinoma, squamous cell, Leukoplakia, Mouth neoplasms, Neoplasms, multiple primary, Neoplasms, second primary
Asian J Oral Maxillofac Surg. 2008;20:74-80.
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