Volume 21, Number 3 & 4, September & December 2009
| | Cervical Lymph Node Metastasis and Histopathological Malignancy Grading of Primary Oral Squamous Cell Carcinoma |
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Takahiro Oneyama,1 Izumi Mataga,2 Masataka Katagiri3
1Department of Oral and Maxillofacial Surgery, Nippon Dental University Niigata Hospital, and 2Department of Oral and Maxillofacial Surgery II and 3Department of Pathology, Nippon Dental University, School of Life Dentistry, Niigata, Japan
Abstract
Objectives: Malignant lesions of patients with primary oral squamous cell carcinoma were examined and graded histologically. The rate of p53-positive findings and the density of microvessels in these lesions were assessed as possible predictors of cervical lymph node metastasis.
Patients and Methods: Forty six patients with primary oral squamous cell carcinoma who underwent neck dissection to excise the primary tumour were included in the study. Malignant lesions were histologically graded and biopsy samples from the primary tumours were immunostained for p53 and CD31.
Result: There were significant differences between the pathological lymph node–positive and pathological lymph node–negative groups for degree of keratinisation, pattern of invasion, and total score. The p53-positive rate showed no statistical significance for any parameter. The density of microvessels was lower in the high malignancy group than in the low malignancy group, but none of the parameters differed significantly. Based on the histological grading of these lesions, the 10-year survival rate was 85.7% for the low malignancy group and 52.0% for the high malignancy group (p < 0.05). No significant difference was found between the p53-positive and p53-negative groups.
Conclusions: Histological grading of malignant primary tumours may predict cervical lymph node metastasis. However, positive findings are influenced by multiple factors, ranging from p53 positivity to the density of microvessels. Further detailed study of the association between these factors is warranted.
Key words: Carcinoma, squamous cell, Genes, p53, Lymphatic metastasis, Microvessels, Neoplasms by histologic type
Asian J Oral Maxillofac Surg. 2009;21:81-87.
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